ADHD is a common neurodevelopmental disorder. It is important for the clinician to keep up-to-date with the new developments in using ADHD medications effectively, while empowering patients and parents to make informed choices. The aim of this paper is to assist the clinician in deciding which medication or formulation to recommend in different circumstances. Ten simple principles of administering ADHD medication are outlined, along with comprehensive tables and a flow chart. An up-to-date summary of the research supporting current practice is presented.