Perhaps as many as 20% of individuals with ADHD will not respond adequately to the three medications recommended in the current NICE guideline. This paper considers treatments that are not recommended in the guideline but appear to be useful in the treatment of ADHD. The effect size and common language effect size (CLES)are definedandare quotedwhere datais available,as a guide to choosing effective alternatives. The alternative medications considered include clonidine, atypical antipsychotics, antidepressants, modafinil, and amantadine.