Purging disorder: considerations for clinical presentation, epidemiology, risk factors and interventions
References
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5). Arlington VA. American Psychiatric Association (2013). https://doi.org/10.1007/springerreference_179660
- Wu XY, Yin WQ, Sun HW, Yang SX, Li XY, Liu HQ. The association between disordered eating and health-related quality of life among children and adolescents: a systematic review of population-based studies. PLoS One. 2019;14(10):e0222777. https://doi.org/10.1371/journal.pone.0222777
- Keel PK, Eckel LA, Hildebrandt BA, Haedt‐Matt AA, Appelbaum J, Jimerson DC. Disturbance of gut satiety peptide in purging disorder. International Journal of Eating Disorders. 2018;51(1):53-61. https://doi.org/10.1002/eat.22806
- World Health Organisation (WHO). International Statistical Classification of Diseases and Related Health Problems (11th ed) 2019. Accessed 15 October 2023. Available from: https://icd.who.int/.
- Quadflieg N, Voderholzer U, Meule A, Fichter MM. Comparing ICD‐11 and DSM‐5 eating disorder diagnoses with the Munich eating and feeding disorder questionnaire (ED‐Quest). International Journal of Eating Disorders 2023;56(9):1826-31. https://doi.org/10.1002/eat.24010
- Glazer KB, Sonneville KR, Micali N, Swanson SA, Crosby R, Horton NJ, et al. The course of eating disorders involving bingeing and purging among adolescent girls: prevalence, stability, and transitions. Journal of Adolescent Health. 2019;64(2):165-71. https://doi.org/10.1016/j.jadohealth.2018.09.023
- Mitchison D, Mond J, Bussey K, Griffiths S, Trompeter N, Lonergan A, et al. DSM-5 full syndrome, other specified, and unspecified eating disorders in Australian adolescents: prevalence and clinical significance. Psychological Medicine. 2020;50(6):981-90. https://doi.org/10.1017/s0033291719000898
- Schaumberg K, Zerwas SC, Bulik CM, Fiorentini C, Micali N. Prospective associations between childhood social communication processes and adolescent eating disorder symptoms in an epidemiological sample. European Child and Adolescent Psychiatry. 2021;30:1929-38. https://doi.org/10.1007/s00787-020-01655-9
- Silén Y, Sipil. PN, Raevuori A, Mustelin L, Marttunen M, Kaprio J, et al. DSM‐5 eating disorders among adolescents and young adults in Finland: a public health concern. International Journal of Eating Disorders. 2020;53(5):790-801. https://doi.org/10.1002/eat.23236
- Garcia SC, Mikhail ME, Keel PK, Burt SA, Neale MC, Boker S, et al. Increased rates of eating disorders and their symptoms in women with major depressive disorder and anxiety disorders. International Journal of Eating Disorders. 2020;53(11):1844-54. https://doi.org/10.1002/eat.23366
- Haedt AA, Keel PK. Comparing definitions of purging disorder on point prevalence and associations with external validators. International Journal of Eating Disorders. 2010;43(5):433-9. https://doi.org/10.1002/eat.20712
- Masheb RM, Ramsey CM, Marsh AG, Decker SE, Maguen S, Brandt CA, et al. DSM‐5 eating disorder prevalence, gender differences, and mental health associations in United States military veterans. International Journal of Eating Disorders. 2021;54(7):1171-80. https://doi.org/10.1002/eat.23501
- Chua SN, Fitzsimmons‐Craft EE, Austin SB, Wilfley DE, Taylor CB. Estimated prevalence of eating disorders in Malaysia based on a diagnostic screen. International Journal of Eating Disorders. 2022;55(6):763-75. https://doi.org/10.1002/eat.23711
- Hübel C, Birgegård A, Johansson T, Petersen LV, Isomaa R, Herle M. Latent anxiety and depression dimensions differ amongst patients with eating disorders: a Swedish nationwide investigation. International Journal of Methods in Psychiatric Research 2023;32(3):e1961. https://doi.org/10.1101/2022.05.25.22275566
- Koch S, Quadflieg N, Fichter M. Purging disorder: a comparison to established eating disorders with purging behaviour. European Eating Disorders Review. 2013;21(4):265-75. https://doi.org/10.1002/erv.2231
- Krug I, Giles SE, Granero R, Agüera Z, S.nchez I, Sánchez‐Gonzalez J, et al. Where does purging disorder lie on the symptomatologic and personality continuum when compared to other eating disorder subtypes? Implications for the DSM. European Eating Disorders Review. 2022;30(1):36-49. https://doi.org/10.1002/erv.2872
- Tasca GA, Maxwell H, Bone M, Trinneer A, Balfour L, Bissada H. Purging disorder: psychopathology and treatment outcomes. International Journal of Eating Disorders. 2012;45(1):36-42. https://doi.org/10.1002/eat.20893
- Vo M, Accurso EC, Goldschmidt AB, Le Grange D. The impact of DSM‐5 on eating disorder diagnoses. International Journal of Eating Disorders. 2017;50(5):578-81. https://doi.org/10.1002/eat.22628
- Nakai Y, Nin K, Noma Si, Teramukai S, Fujikawa K, Wonderlich SA. Changing profile of eating disorders between 1963 and 2004 in a Japanese sample. International Journal of Eating Disorders. 2018;51(8):953-8. https://doi.org/10.1002/eat.22935
- Bodell LP, Egbert AH, Anaya C, Wildes JE. Associations between emotion reactivity and eating disorder symptoms in a transdiagnostic treatment‐seeking sample. International Journal of Eating Disorders. 2022;55(10):1390-6. https://doi.org/10.1002/eat.23808
- Grillot CL, Keel PK. Barriers to seeking treatment for eating disorders: the role of self‐recognition in understanding gender disparities in who seeks help. International Journal of Eating Disorders. 2018;51(11):1285-9. https://doi.org/10.1002/eat.22965
- Ali K, Farrer L, Fassnacht DB, Gulliver A, Bauer S, Griffiths KM. Perceived barriers and facilitators towards help‐seeking for eating disorders: a systematic review. International Journal of Eating Disorders. 2017;50(1):9-21. https://doi.org/10.1002/eat.22598
- Fatt SJ, Mond J, Bussey K, Griffiths S, Murray SB, Lonergan A, et al. Seeing yourself clearly: self‐identification of a body image problem in adolescents with an eating disorder. Early Intervention in Psychiatry. 2021;15(3):577-84. https://doi.org/10.1111/eip.12987
- Liu L, Hay P, Conti J. Perspectives on barriers to treatment engagement of people with eating disorder symptoms who have not undergone treatment: a qualitative study. BMC Psychiatry. 2022;22(1):1-11. https://doi.org/10.1186/s12888-022-03890-7
- McLean SA, Caldwell B, Robertson M. Reach Out and Recover: Intentions to seek treatment in individuals using online support for eating disorders. International Journal of Eating Disorders. 2019;52(10):1137-49. https://doi.org/10.1002/eat.23133
- Silén Y, Sipil. PN, Raevuori A, Mustelin L, Marttunen M, Kaprio J, et al. Detection, treatment, and course of eating disorders in Finland: a population‐based study of adolescent and young adult females and males. European Eating Disorders Review. 2021;29(5):720-32. https://doi.org/10.1002/erv.2838
- Swanson SA, Brown TA, Crosby RD, Keel PK. What are we missing? The costs versus benefits of skip rule designs. International Journal of Methods in Psychiatric Research. 2014;23(4):474-85. https://doi.org/10.1002/mpr.1396
- Mouchabac S, Conejero I, Lakhlifi C, Msellek I, Malandain L, Adrien V, et al. Improving clinical decision-making in psychiatry: implementation of digital phenotyping could mitigate the influence of patient's and practitioner's individual cognitive biases. Dialogues in Clinical Neuroscience. 2021;23(1):52-61. https://doi.org/10.1080/19585969.2022.2042165
- Wilkop M, Wade T, Keegan E, Cohen-Woods S. Impairments among DSM-5 eating disorders: a systematic review and multilevel metaanalysis. Clinical Psychology Review. 2023:102267. https://doi.org/10.1016/j.cpr.2023.102267
- Stice E, Gau JM, Rohde P, Shaw H. Risk factors that predict future onset of each DSM–5 eating disorder: Predictive specificity in high-risk adolescent females. Journal of Abnormal Psychology. 2017;126(1):38. https://doi.org/10.1037/abn0000219
- Keel PK, Mayer SA, Harnden‐Fischer JH. Importance of size in defining binge eating episodes in bulimia nervosa. International Journal of Eating Disorders. 2001;29(3):294-301. https://doi.org/10.1002/eat.1021
- Davis HA, Smith GT, Keel PK. An examination of negative urgency and other impulsigenic traits in purging disorder. Eating Behaviors. 2020;36:101365. https://doi.org/10.1016/j.eatbeh.2020.101365
- Wade TD. A retrospective comparison of purging type disorders: eating disorder not otherwise specified and bulimia nervosa. International Journal of Eating Disorders. 2007;40(1):1-6. https://doi.org/10.1002/eat.20314
- Liebman RE, Coniglio KA, Becker KR, Tabri N, Keshishian AC, Wons O, et al. Behavioral inhibition moderates the association between overvaluation of shape and weight and noncompensatory purging in eating disorders. International Journal of Eating Disorders. 2020;53(1):143-8. https://doi.org/10.1002/eat.23195
- Munn-Chernoff MA, Few LR, Matherne CE, Baker JH, Men VY, McCutcheon VV, et al. Eating disorders in a community-based sample of women with alcohol use disorder and nicotine dependence. Drug and Alcohol Dependence. 2020;212:107981. https://doi.org/10.1016/j.drugalcdep.2020.107981
- Keel PK, Haedt-Matt AA, Hildebrandt B, Bodell LP, Wolfe BE, Jimerson DC. Satiation deficits and binge eating: probing differences between bulimia nervosa and purging disorder using an ad lib test meal. Appetite. 2018;127:119-25. https://doi.org/10.1016/j.appet.2018.04.009
- Keel PK, Striegel‐Moore RH. The validity and clinical utility of purging disorder. International Journal of Eating Disorders. 2009;42(8):706-19. https://doi.org/10.1002/eat.20718
- Keel PK, Wolfe BE, Liddle RA, De Young KP, Jimerson DC. Clinical features and physiological response to a test meal in purging disorder and bulimia nervosa. Archives of General Psychiatry. 2007;64(9):1058-66. https://doi.org/10.1001/archpsyc.64.9.1058
- Dossat AM, Bodell LP, Williams DL, Eckel LA, Keel PK. Preliminary examination of glucagon‐like peptide‐1 levels in women with purging disorder and bulimia nervosa. International Journal of Eating Disorders. 2015;48(2):199-205. https://doi.org/10.1002/eat.22264
- Maske CB, Williams DL, Keel PK. Preliminary examination of insulin and amylin levels in women with purging disorder. International Journal of Eating Disorders. 2020;53(6):997-1001. https://doi.org/10.1002/eat.23230
- Keel PK, Eckel LA, Hildebrandt BA, Haedt-Matt AA, Murry DJ, Appelbaum J, et al. Disentangling the links between gastric emptying and binge eating v. purging in eating disorders using a case-control design. Psychological Medicine. 2023;53(5):1947-54. https://doi.org/10.1017/s0033291721003640
- Golding J. The Avon Longitudinal Study of Parents and Children (ALSPAC)--study design and collaborative opportunities. European Journal of Endocrinology. 2004;151(Supplement_3):U119-U23. https://doi.org/10.1530/eje.0.151u119
- Yilmaz Z, Gottfredson NC, Zerwas SC, Bulik CM, Micali N. Developmental premorbid body mass index trajectories of adolescents with eating disorders in a longitudinal population cohort. Journal of the American Academy of Child and Adolescent Psychiatry. 2019;58(2):191-9. https://doi.org/10.1016/j.jaac.2018.11.008
- Stice E, Desjardins CD. Interactions between risk factors in the prediction of onset of eating disorders: Exploratory hypothesis generating analyses. Behaviour Research and Therapy. 2018;105:52-62. https://doi.org/10.1016/j.brat.2018.03.005
- Haedt-Matt AA, Keel PK. Affect regulation and purging: an ecological momentary assessment study in purging disorder. Journal of Abnormal Psychology. 2015;124(2):399. https://doi.org/10.1037/a0038815
- D'Adamo L, Ghaderi A, Rohde P, Gau JM, Shaw H, Stice E. Evaluating whether a peer-led dissonance-based eating disorder prevention program prevents onset of each eating disorder type. Psychological Medicine. 2023:1-8. https://doi.org/10.1017/s0033291723000739
- Fairburn CG, Cooper D Phil DP, Zafra, Doll D Phil HA, O'Connor ME, Bohn D Phil DP, Kristin, Hawker DM, et al. Transdiagnostic cognitivebehavioral therapy for patients with eating disorders: a two-site trial with 60-week follow-up. American Journal of Psychiatry. 2009;166(3):311-9. https://doi.org/10.1176/appi.ajp.2008.08040608
- Le Grange D, Crosby RD, Rathouz PJ, Leventhal BL. A randomized controlled comparison of family-based treatment and supportive psychotherapy for adolescent bulimia nervosa. Archives of General Psychiatry. 2007;64(9):1049-56. https://doi.org/10.1001/archpsyc.64.9.1049
- MacDonald DE, McFarlane TL, Dionne MM, David L, Olmsted MP. Rapid response to intensive treatment for bulimia nervosa and purging disorder: a randomized controlled trial of a CBT intervention to facilitate early behavior change. Journal of Consulting and Clinical Psychology. 2017;85(9):896. https://doi.org/10.1037/ccp0000221
- Schmidt U, Lee S, Beecham J, Perkins S, Treasure J, Yi I, et al. A randomized controlled trial of family therapy and cognitive behavior therapy guided self-care for adolescents with bulimia nervosa and related disorders. American Journal of Psychiatry. 2007;164(4):591-8. https://doi.org/10.1176/appi.ajp.164.4.591
- Riesco N, Agüera Z, Granero R, Jiménez-Murcia S, Menchón JM, Fernández-Aranda F. Other Specified Feeding or Eating Disorders (OSFED): clinical heterogeneity and cognitive-behavioral therapy outcome. European Psychiatry. 2018;54:109-16. https://doi.org/10.1016/j.eurpsy.2018.08.001
- Fernández‐Aranda F, Treasure J, Paslakis G, Agüera Z, Gimenez M, Granero R, et al. The impact of duration of illness on treatment nonresponse and drop‐out: exploring the relevance of enduring eating disorder concept. European Eating Disorders Review. 2021;29(3):499-513. https://doi.org/10.1002/erv.2822
- Sysko R, Hildebrandt T. Enhanced cognitive behavioural therapy for an adolescent with purging disorder: a case report. European Eating Disorders Review. 2011;19(1):37-45. https://doi.org/10.1002/erv.1044
- Keel PK. The Void Inside: Bringing Purging Disorder to Light. New York. Oxford University Press (2020). https://doi.org/10.1093/med-psych/9780190061166.001.0001
- Koch S, Quadflieg N, Fichter M. Purging disorder: a pathway to death? A review of 11 cases. Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity. 2014;19:21-9. https://doi.org/10.1007/s40519-013-0082-3
- Forney KJ, Crosby RD, Brown TA, Klein KM, Keel PK. A naturalistic, long-term follow-up of purging disorder. Psychological Medicine. 2021;51(6):1020-7. https://doi.org/10.1017/s0033291719003982
- Forney KJ, Brown TA, Crosby RD, Klein KM, Keel PK. Evaluating the predictive validity of purging disorder by comparison to bulimia nervosa at long‐term follow‐up. International Journal of Eating Disorders. 2022;55(6):810-9. https://doi.org/10.1002/eat.23712
- Williams D, Keel P. Neuroendocrine function and the gut-brain axis in eating disorders. In: Steinglass J, Wierenga C (eds). Handbook of the Neurobiology of Eating Disorders. New York. Oxford University Press (2024). https://doi.org/10.1093/9780197675212.003.0004